I have not yet downloaded it, but I have seen it being played, and it looks much better than Frets on Fire. It does work with the Wiimote/Wiiguitar if you have bluetooth or a bluetooth adapter on your computer, as the wiimote uses a bluetooth connection to the wii, and an infared to the sensor bar. (the only reason for the cord is to give power. Thus, all the sensor bar is is two infared lights.) You may have to use glovepie or some other similar emulator for this. It will work with the PS3, PC and 360 guitars and also the PS2 guitar if you get the ps2-usb adapter (Not the ps/2 usb adapter. That is for mice and keyboards. There is one made by pelican) You can also use the regular keyboard. If it does not work from the start, try using glovepie to emulate a joystick.